Synthesis and Glutathione Peroxidase-like activity of N-heterocyclic carbene derived cationic diselenides
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Title |
Synthesis and Glutathione Peroxidase-like activity of N-heterocyclic carbene derived cationic diselenides
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Creator |
MANJARE, ST
SINGH, HB BUTCHER, RJ |
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Subject |
Cationic diselenides
GPx Selenone Oxidation reaction Selenium dioxide THYROID-HORMONE SYNTHESIS CRYSTAL-STRUCTURE ORGANOSELENIUM COMPOUNDS ANTIOXIDANT ACTIVITY REMARKABLE ACTIVITY DIARYL DISELENIDES ANTITHYROID DRUGS IN-SITU EBSELEN DERIVATIVES |
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Description |
Water soluble cationic diselenide derivatives of benzimidazolin-2-selenones and imidazolin-2-selenones have been synthesized. The Glutathione Peroxidase-like (GPx-like) activities of cationic diselenides have been investigated for the first time. The GPx-like activities are found to be quite low as compared to the neutral imidazole based diselenide and intramolecularly coordinated diselenides. A mechanism for GPx-like activity has been proposed. The oxidation reactions of N-heterocyclic carbene derived selenones with hydrogen peroxide have been studied. (C) 2012 Elsevier Ltd. All rights reserved.
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Publisher |
PERGAMON-ELSEVIER SCIENCE LTD
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Date |
2014-10-15T16:42:12Z
2014-10-15T16:42:12Z 2012 |
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Type |
Article
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Identifier |
TETRAHEDRON, 68(51)10561-10566
http://dx.doi.org/10.1016/j.tet.2012.09.024 http://dspace.library.iitb.ac.in/jspui/handle/100/15237 |
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Language |
en
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