Record Details

Synthesis and Glutathione Peroxidase-like activity of N-heterocyclic carbene derived cationic diselenides

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Synthesis and Glutathione Peroxidase-like activity of N-heterocyclic carbene derived cationic diselenides
 
Creator MANJARE, ST
SINGH, HB
BUTCHER, RJ
 
Subject Cationic diselenides
GPx
Selenone
Oxidation reaction
Selenium dioxide
THYROID-HORMONE SYNTHESIS
CRYSTAL-STRUCTURE
ORGANOSELENIUM COMPOUNDS
ANTIOXIDANT ACTIVITY
REMARKABLE ACTIVITY
DIARYL DISELENIDES
ANTITHYROID DRUGS
IN-SITU
EBSELEN
DERIVATIVES
 
Description Water soluble cationic diselenide derivatives of benzimidazolin-2-selenones and imidazolin-2-selenones have been synthesized. The Glutathione Peroxidase-like (GPx-like) activities of cationic diselenides have been investigated for the first time. The GPx-like activities are found to be quite low as compared to the neutral imidazole based diselenide and intramolecularly coordinated diselenides. A mechanism for GPx-like activity has been proposed. The oxidation reactions of N-heterocyclic carbene derived selenones with hydrogen peroxide have been studied. (C) 2012 Elsevier Ltd. All rights reserved.
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2014-10-15T16:42:12Z
2014-10-15T16:42:12Z
2012
 
Type Article
 
Identifier TETRAHEDRON, 68(51)10561-10566
http://dx.doi.org/10.1016/j.tet.2012.09.024
http://dspace.library.iitb.ac.in/jspui/handle/100/15237
 
Language en