One-Pot, Two-Step Conversion of Aldehydes to Phosphonyl- and Sulfonylpyrazoles Using Bestmann-Ohira Reagent
DSpace at IIT Bombay
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Title |
One-Pot, Two-Step Conversion of Aldehydes to Phosphonyl- and Sulfonylpyrazoles Using Bestmann-Ohira Reagent
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Creator |
KUMAR, R
VERMA, D MOBIN, SM NAMBOOTHIRI, INN |
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Subject |
BASE-MEDIATED REACTION
REGIOSELECTIVE SYNTHESIS DIAZOCARBONYL COMPOUNDS BIOLOGICAL-ACTIVITY PYRAZOLE SYNTHESIS CARBONYL-COMPOUNDS CYCLOADDITION DERIVATIVES CHEMISTRY ALKYNES |
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Description |
A one-pot, two-step, three-component method for the conversion of commercially available aldehydes to phosphonylpyrazoles has been developed, demonstrating, for the first time, the dual reactivity of the Bestmann-Ohira reagent (BOR) in a single-pot transformation. This method, extended to the synthesis of sulfonylpyrazoles by employing BOR in the first step and a diazomethyl sulfone in the second step, is complementary, with regard to regioselectivity, to the previous methods for the synthesis of such functionalized pyrazoles.
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Publisher |
AMER CHEMICAL SOC
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Date |
2014-10-16T05:36:36Z
2014-10-16T05:36:36Z 2012 |
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Type |
Article
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Identifier |
ORGANIC LETTERS, 14(16)4070-4073
http://dx.doi.org/10.1021/ol301695e http://dspace.library.iitb.ac.in/jspui/handle/100/15353 |
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Language |
en
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