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One-Pot, Two-Step Conversion of Aldehydes to Phosphonyl- and Sulfonylpyrazoles Using Bestmann-Ohira Reagent

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Title One-Pot, Two-Step Conversion of Aldehydes to Phosphonyl- and Sulfonylpyrazoles Using Bestmann-Ohira Reagent
 
Creator KUMAR, R
VERMA, D
MOBIN, SM
NAMBOOTHIRI, INN
 
Subject BASE-MEDIATED REACTION
REGIOSELECTIVE SYNTHESIS
DIAZOCARBONYL COMPOUNDS
BIOLOGICAL-ACTIVITY
PYRAZOLE SYNTHESIS
CARBONYL-COMPOUNDS
CYCLOADDITION
DERIVATIVES
CHEMISTRY
ALKYNES
 
Description A one-pot, two-step, three-component method for the conversion of commercially available aldehydes to phosphonylpyrazoles has been developed, demonstrating, for the first time, the dual reactivity of the Bestmann-Ohira reagent (BOR) in a single-pot transformation. This method, extended to the synthesis of sulfonylpyrazoles by employing BOR in the first step and a diazomethyl sulfone in the second step, is complementary, with regard to regioselectivity, to the previous methods for the synthesis of such functionalized pyrazoles.
 
Publisher AMER CHEMICAL SOC
 
Date 2014-10-16T05:36:36Z
2014-10-16T05:36:36Z
2012
 
Type Article
 
Identifier ORGANIC LETTERS, 14(16)4070-4073
http://dx.doi.org/10.1021/ol301695e
http://dspace.library.iitb.ac.in/jspui/handle/100/15353
 
Language en