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Cu(II) complexes of glyco-imino-aromatic conjugates in DNA binding, plasmid cleavage and cell cytotoxicity

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Title Cu(II) complexes of glyco-imino-aromatic conjugates in DNA binding, plasmid cleavage and cell cytotoxicity
 
Creator KUMAR, A
MITRA, A
AJAY, AK
BHAT, MK
RAO, CP
 
Subject Glyco-metal-complexes
DNA cleavage
cytotoxicity
apoptosis
LIGAND COPPER(II) COMPLEXES
DIIMINE CO-LIGANDS
ANTICANCER COMPLEXES
GOLD(I) COMPLEXES
RECOGNITION
DERIVATIVES
ANTIFUNGAL
ACID
FLUORESCENCE
DOCKING
 
Description Binding of metal complexes of C2-glucosyl conjugates with DNA has been established by absorption and fluorescence studies. Conformational changes occurred in DNA upon binding have been studied by circular dichroism. All these studies are suggestive that the metal complexes bind to DNA through intercalation. Binding of di-nuclear copper complex 5 was found to be stronger when compared to the other complexes studied. Copper complexes were found to cleave the plasmid DNA in the absence of oxidizing or reducing agent, whereas, zinc complexes do not cleave. Metal complexes have shown toxicity to the HeLa and MCF-7 cell lines. Morphological studies, western blot and FACS analysis are suggestive of apoptotic cell death induced by the metal complexes. Di-nuclear copper complexes were found to be better as compared to the mononuclear ones in binding, plasmid cleavage and also in causing more cell death.
 
Publisher INDIAN ACAD SCIENCES
 
Date 2014-10-16T05:51:37Z
2014-10-16T05:51:37Z
2012
 
Type Article
 
Identifier JOURNAL OF CHEMICAL SCIENCES, 124(6)1217-1228
http://dx.doi.org/10.1007/s12039-012-0319-0
http://dspace.library.iitb.ac.in/jspui/handle/100/15383
 
Language en