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Synthesis of Modified Phenylalanine Peptides by Cross Enyne Metathesis and a Diels-Alder Reaction as Key Steps

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Field Value
 
Title Synthesis of Modified Phenylalanine Peptides by Cross Enyne Metathesis and a Diels-Alder Reaction as Key Steps
 
Creator KOTHA, S
GOYAL, D
THOTA, N
SRINIVAS, V
 
Subject Metathesis
Diels-Alder reaction
Peptides
Diversity oriented approach
Synthesis design
RING-CLOSING METATHESIS
AMINO-ACID DERIVATIVES
ORIENTED ORGANIC-SYNTHESIS
BUILDING-BLOCK APPROACH
RUTHENIUM COMPLEXES
OLEFIN METATHESIS
COUPLING REACTION
DIVERSITY
BACKBONE
ANALOGS
 
Description Modified phenylalanine-based di- and tripeptides have been efficiently assembled by cross enyne metathesis and a DielsAlder reaction as key steps under mild conditions. In all cases, peptide integrity was preserved, no racemisation was observed, and good yields of modified peptides were obtained.
 
Publisher WILEY-V C H VERLAG GMBH
 
Date 2014-10-16T06:07:09Z
2014-10-16T06:07:09Z
2012
 
Type Article
 
Identifier EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (9)1843-1850
http://dx.doi.org/10.1002/ejoc.201101744
http://dspace.library.iitb.ac.in/jspui/handle/100/15414
 
Language en