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Diversity-Oriented Approach to Novel Spirocyclics via Enyne Metathesis, Diels-Alder Reaction, and a [2+2+2] Cycloaddition as Key Steps

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Title Diversity-Oriented Approach to Novel Spirocyclics via Enyne Metathesis, Diels-Alder Reaction, and a [2+2+2] Cycloaddition as Key Steps
 
Creator KOTHA, S
ALI, R
TIWARI, A
 
Subject spirocyclic compounds
[2+2+2]-cycloaddition reaction
rongalite
enyne metathesis
Diels-Alder reaction
AMINO-ACID DERIVATIVES
RING-CLOSING METATHESIS
FREDERICAMYCIN-A
MOLECULAR FRAMEWORKS
GLYCINE EQUIVALENT
ORGANIC-SYNTHESIS
O-QUINODIMETHANE
TIC DERIVATIVES
FENESTRANES
EXPANSION
 
Description A simple protocol for the synthesis of indane-based spirocyclics has been developed via enyne metathesis, Diels-Alder reaction, and a [2+2+2] cycloaddition as key steps starting from indane-1,3-dione. The key diene building block was assembled by enyne metathesis. In this sequence, rongalite is used as a green reagent to prepare the sultine intermediate, which is a useful precursor to generate the transient diene.
 
Publisher GEORG THIEME VERLAG KG
 
Date 2014-10-16T06:10:09Z
2014-10-16T06:10:09Z
2013
 
Type Article
 
Identifier SYNLETT, 24(15)1921-1926
0936-5214
1437-2096
http://dx.doi.org/10.1055/s-0033-1339489
http://dspace.library.iitb.ac.in/jspui/handle/100/15420
 
Language en