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Nanovesicle aerosols as surfactant therapy in lung injury

DSpace at IIT Bombay

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Field Value
 
Title Nanovesicle aerosols as surfactant therapy in lung injury
 
Creator KAVIRATNA, AS
BANERJEE, R
 
Subject Nanovesicles
Acute lung injury
Airway patency
Surfactant therapy
PH-SENSITIVE LIPOSOMES
PULMONARY SURFACTANT
ACID ASPIRATION
A549 CELLS
MICROSPHERES
INSTILLATION
PROTEINS
ALVEOLAR
MODEL
 
Description Acute lung injury causes inactivation of pulmonary surfactant due to leakage of albumin and other markers. Current surfactants are ineffective in this condition and are instilled intratracheally. Nanovesicles of 300 +/- 50 nm composed of nonlamellar phospholipids were developed as pulmonary surfactant aerosols for therapy in acid-induced lung injury. A combination of dipalmitoyl phosphatidylcholine and dioleoyl phosphatidylethanolamine was used. The size and composition of the nanovesicles were optimized for an improved airway patency in the presence of albumin and serum. In an acid-induced lung injury model in mice, on treatment with nanovesicle aerosols at a dose of 200 mg/kg, the alveolar protein leakage decreased from 8.62 +/- 0.97 mu g/mL to 1.94 +/- 0.74 mu g/mL, whereas the airway patency of the bronchoalveolar lavage fluid increased from 0.6 +/- 0.0% to 91.7 +/- 1.05%. Nanovesicle aerosols of nonlamellar lipids improved the resistance of pulmonary surfactants to inhibition and were promising as a noninvasive aerosol therapy in acute lung injury.
 
Publisher ELSEVIER SCIENCE BV
 
Date 2014-10-16T06:47:10Z
2014-10-16T06:47:10Z
2012
 
Type Article
 
Identifier NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 8(5)665-672
http://dx.doi.org/10.1016/j.nano.2011.08.004
http://dspace.library.iitb.ac.in/jspui/handle/100/15471
 
Language en