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A comparative study on thermoresponsive magnetic nanohydrogels: role of surface-engineered magnetic nanoparticles

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Title A comparative study on thermoresponsive magnetic nanohydrogels: role of surface-engineered magnetic nanoparticles
 
Creator JAISWAL, MK
MEHTA, S
BANERJEE, R
BAHADUR, D
 
Subject Thermoresponsive polymers
Poly(N-isopropylacrylamide)
Chitosan
Iron oxide nanoparticles
LCST
IRON-OXIDE
TEMPERATURE
MICROGELS
RELEASE
IMMOBILIZATION
DOXORUBICIN
COPOLYMERS
 
Description A comparative study of thermoresponsive poly(N-isopropylacrylamide)(PNIPAAm)-chitosan (CS)-based magnetic nanohydrogels (MNHGs) encapsulating functionalized Fe3O4 nanoparticles (NPs) in terms of the parameters governing their suitability for real hyperthermia is reported. Iron oxide NPs functionalized with (a) citric acid (CA-Fe3O4), (b) ethylenediamine (Amine-Fe3O4) and (c) dimercaptosuccininc (DMSA-Fe3O4) have been synthesized and their encapsulation into MNHGs was obtained through physical encapsulation method. The structural characterizations of synthesized materials include X-ray diffraction, FT-IR, TGA, ICP-AES and X-ray photoelectron spectroscopy (XPS). Encapsulation of the functionalized NPs into MNHGs were observed in TEM micrographs, while SEM and AFM micrographs confirmed their spherical morphology (similar to 250-300 nm). Lower critical solution temperature (LCST) variation was measured by UV-visible spectrophotometer and differential scanning calorimetry (DSC). MNHGs exhibited sufficient magnetization and heating ability for hyperthermia. Typically, hydrogels containing CA-Fe3O4 (50 mg/ml) raised the temperature of the medium to 43 A degrees C, a suitable dose for in vivo application in tumor-bearing mice.
 
Publisher SPRINGER
 
Date 2014-10-16T12:41:37Z
2014-10-16T12:41:37Z
2012
 
Type Article
 
Identifier COLLOID AND POLYMER SCIENCE, 290(7)607-617
http://dx.doi.org/10.1007/s00396-011-2572-z
http://dspace.library.iitb.ac.in/jspui/handle/100/15573
 
Language en