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History-Dependent Depolymerization of Actin Filaments

DSpace at IIT Bombay

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Field Value
 
Title History-Dependent Depolymerization of Actin Filaments
 
Creator JAIN, I
LACOSTE, D
PANDA, D
PADINHATEER, R
 
Subject ATP-HYDROLYSIS
POLYMERIZATION DYNAMICS
FLUCTUATIONS
MICROTUBULES
INSTABILITY
LENGTH
 
Description Depolymerizing cytoskeletal filaments are involved in cell division, cell motility, and other cellular functions. Understanding the dynamics of depolymerization is as important as understanding the dynamics of polymerization. We study nonequilibrium depolymerization of actin filaments using a simple two-state model. We show that the polymerization history influences the dynamics of depolymerization as well as the length fluctuations during depolymerization. We also simulate depolymerization under different experimentally feasible conditions. Under conditions of constant concentration, we show that the depolymerization happens in two regimes. Under the conditions of mass conservation, the depolymerization can have three regimes.
 
Publisher AMER CHEMICAL SOC
 
Date 2014-10-16T12:45:08Z
2014-10-16T12:45:08Z
2012
 
Type Article
 
Identifier BIOCHEMISTRY, 51(38)7580-7587
http://dx.doi.org/10.1021/bi300629f
http://dspace.library.iitb.ac.in/jspui/handle/100/15580
 
Language en