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Association of GST null genotypes with anti-tuberculosis drug induced hepatotoxicity in Western Indian population

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Title Association of GST null genotypes with anti-tuberculosis drug induced hepatotoxicity in Western Indian population
 
Creator GUPTA, VH
SINGH, M
AMARAPURKAR, DN
SASI, P
JOSHI, JM
BAIJAL, R
KUMAR, HRP
AMARAPURKAR, AD
JOSHI, K
WANGIKAR, PP
 
Subject Drug induced hepatotoxicity
Phase II enzymes
Homozygous null mutation
Case-control study
GLUTATHIONE-S-TRANSFERASE
INDUCED LIVER-INJURY
GENETIC POLYMORPHISMS
INDUCED HEPATITIS
INCREASED RISK
M1
METAANALYSIS
T1
SUSCEPTIBILITY
DELETIONS
 
Description Background. The first line anti-tubercular (anti-TB) treatment normally involves isoniazid, rifampicin, pyrazinamide, and ethambutol. Clearance of these drugs depends on the activity of several enzymes such as N-acetyl transferase 2, cytochrome P450 oxidase and glutathione S-transferase (GST). Some of these enzymes are highly polymorphic leading to significant inter-individual variation in their activity thereby increasing the risk of drug induced hepatotoxicity (DIH). Aim. To investigate the possible association of anti-TB D1H with genetic polymorphism of GST genes in Western Indian population. Material and methods. A prospective case-control study was undertaken on patients who received anti-TB treatment. Cases (n = 50) were distinguished from controls (n = 246) based on occurrence of DIH during anti-tubercular treatment. A multiplex polymerase chain reaction was employed to identify homozygous null mutation at GSTM1 and GSTT1 loci. Results. Homozygous null mutation in GSTM1 gene alone or in both GSTM1 and T1 genes was found to be significantly associated with anti-TB DIH at p < 0.02 and p < 0.007, respectively, in our study population. Conclusions. This is the first study to report GSTM1 null and combined GSTM1 and T1 null genotypes to be risk factors of anti-TB DIH in Western Indian population. Screening of patients for these genotypes prior to anti-TB regimen would provide better control of hepatotoxicity.
 
Publisher MEXICAN ASSOC HEPATOLOGY
 
Date 2014-10-16T13:08:19Z
2014-10-16T13:08:19Z
2013
 
Type Article
 
Identifier ANNALS OF HEPATOLOGY, 12(6)959-965
http://dspace.library.iitb.ac.in/jspui/handle/100/15626
 
Language en