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Investigation of serum proteome alterations in human glioblastoma multiforme

DSpace at IIT Bombay

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Title Investigation of serum proteome alterations in human glioblastoma multiforme
 
Creator GOLLAPALLI, K
RAY, S
SRIVASTAVA, R
RENU, D
SINGH, P
DHALI, S
DIKSHIT, JB
SRIKANTH, R
MOIYADI, A
SRIVASTAVA, S
 
Subject Biomedicine
2D-DIGE
Glioblastoma multiforme
Glioma
Serum biomarker
D-BINDING PROTEIN
PRIMARY BRAIN-TUMORS
CANCER-PATIENTS
NERVOUS-SYSTEM
GROWTH-FACTOR
GLIOMAS
CHOLESTEROL
IDENTIFICATION
CERULOPLASMIN
MALIGNANCY
 
Description Glioblastoma multiforme (GBM) or grade IV astrocytoma is the most common and lethal adult malignant brain tumor. The present study was conducted to investigate the alterations in the serum proteome in GBM patients compared to healthy controls. Comparative proteomic analysis was performed employing classical 2DE and 2D-DIGE combined with MALDI TOF/TOF MS and results were further validated through Western blotting and immunoturbidimetric assay. Comparison of the serum proteome of GBM and healthy subjects revealed 55 differentially expressed and statistically significant (p
 
Publisher WILEY-BLACKWELL
 
Date 2014-10-16T13:26:59Z
2014-10-16T13:26:59Z
2012
 
Type Article
 
Identifier PROTEOMICS, 12(14)2378-2390
http://dx.doi.org/10.1002/pmic.201200002
http://dspace.library.iitb.ac.in/jspui/handle/100/15663
 
Language en