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Arundic Acid a Potential Neuroprotective Agent: Biological Development and Syntheses

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Title Arundic Acid a Potential Neuroprotective Agent: Biological Development and Syntheses
 
Creator FERNANDES, RA
INGLE, AB
 
Subject Alzheimer's disease
astrocyte modulation
ischemic stroke
neuroprotection
Parkinson's disease
synthesis
ASTROCYTE-MODULATING AGENT
KNOCK-IN MICE
ALZHEIMER (R)-ARUNDIC ACID
DELAYED INFARCT EXPANSION
PERMANENT FOCAL ISCHEMIA
DIACETONE D-GLUCOSE
THERAPEUTIC AGENT
NITRIC-OXIDE
CLAISEN REARRANGEMENT
DOPAMINERGIC-NEURONS
 
Description Arundic acid has been experimented in vitro and in vivo as a potential neuroprotective agent. It modulates astrocyte activation by inhibiting the enhanced astrocytic synthesis of S-100 beta protein, responsible for inducing neuronal death. The phase II clinical trials for the treatment of acute ischemic stroke, as well as clinical development in other neurodegenerative diseases including amytrophic lateral sclerosis, Alzheimer's disease and Parkinson's disease are recently completed. There is no review published in this area since its discovery as potential neuroprotective agent and the various syntheses reported for this important non-natural compound. This review summarizes the studies towards the development of arundic acid as a neuroprotective agent, the biological studies in vitro and in vivo, the phase II trials and the various efforts made for its synthesis in the last two decades.
 
Publisher BENTHAM SCIENCE PUBL LTD
 
Date 2014-10-16T14:05:50Z
2014-10-16T14:05:50Z
2013
 
Type Article
 
Identifier CURRENT MEDICINAL CHEMISTRY, 20(18)2315-2329
http://dspace.library.iitb.ac.in/jspui/handle/100/15740
 
Language en