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A 12-membered to a strained 11-membered ring: first stereoselective total synthesis of (-)-asteriscunolide C

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Title A 12-membered to a strained 11-membered ring: first stereoselective total synthesis of (-)-asteriscunolide C
 
Creator FERNANDES, RA
CHAVAN, VP
 
Subject ENANTIOSELECTIVE TOTAL-SYNTHESIS
CLOSING METATHESIS
OLEFIN METATHESIS
ASTERISCUNOLIDE-D
ALDEHYDES
LACTONES
FRAGMENT
STRATEGY
CATALYST
ANALOGS
 
Description The first stereoselective total synthesis of (-)-asteriscunolide C has been accomplished in 12 steps in a 16% overall yield. The key step is the conversion of a 12-membered to a strained 11-membered ring with one Z- and two E-double bonds employing a late stage ring-closing metathesis.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2014-10-16T14:08:21Z
2014-10-16T14:08:21Z
2013
 
Type Article
 
Identifier CHEMICAL COMMUNICATIONS, 49(32)3354-3356
http://dx.doi.org/10.1039/c3cc00316g
http://dspace.library.iitb.ac.in/jspui/handle/100/15745
 
Language en