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Triazole linked lower rim glycosyl appended 1,3-calix[4]arene conjugates: Synthesis, characterization, and their interaction with jacalin

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Title Triazole linked lower rim glycosyl appended 1,3-calix[4]arene conjugates: Synthesis, characterization, and their interaction with jacalin
 
Creator CHINTA, JP
RAO, CP
 
Subject Calix[4]arene glyco conjugates
1,3-Dipolar addition
Trp recognition
Interaction of conjugates with jacalin
Fluorescence and circular dichroism
AMINO-ACIDS
O-GLYCOSYL
RECOGNITION
RECEPTORS
PORPHYRIN
DOCKING
LECTINS
BINDING
 
Description Triazole linked lower rim galactosyl and lactosyl appended calix[4]arene conjugates have been synthesized by 1,3 dipolar addition of glycosyl azide and calix[4]arene alkyne. All these conjugates were characterized by H-1 and C-13 NMR, IR and mass spectrometry. Interaction of amino acids with the galactosyl conjugate of calix[4]arene (5) was studied using absorption and H-1 NMR techniques. Absorption studies showed that Trp interacts with triazole ring of 5. This was further confirmed by H-1 NMR study which showed an upfield shift in the triazole proton of 5 upon titrating with Trp. The preliminary studies of interaction of these conjugates with Jacalin were demonstrated by fluorescence and circular dichroism (CD) spectroscopy techniques. (C) 2012 Elsevier Ltd. All rights reserved.
 
Publisher ELSEVIER SCI LTD
 
Date 2014-10-16T15:20:39Z
2014-10-16T15:20:39Z
2013
 
Type Article
 
Identifier CARBOHYDRATE RESEARCH, 36958-62
http://dx.doi.org/10.1016/j.carres.2012.09.010
http://dspace.library.iitb.ac.in/jspui/handle/100/15888
 
Language en