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Study of the Charge Distribution on Liposome Particles Aerosolized by Air-Jet Atomization

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Title Study of the Charge Distribution on Liposome Particles Aerosolized by Air-Jet Atomization
 
Creator CHADHA, TS
CHATTOPADHYAY, S
VENKATARAMAN, C
BISWAS, P
 
Subject liposome
pulmonary delivery
atomization
charge distribution
tandem DMA
spray electrification
PULMONARY DELIVERY
HUMAN AIRWAYS
SIZE RANGE
DRUG
DEPOSITION
DROPLETS
RELEASE
INSULIN
FORCES
MODEL
 
Description Background: Air-jet atomization is a common technique used for the generation of therapeutic aerosols from liposome suspensions for drug delivery to the lungs. Although the technique does not use an electric field, the aerosols generated by this technique are still charged, and this may affect respiratory drug deposition. Methods: In this study, the charge distribution of liposomes aerosolized by an air-jet atomizer was measured using a tandem differential mobility analyzer (TDMA) technique. The liposomes, composed of a mixture of two amphiphilic lipids and cholesterol, were synthesized by the dehydration-rehydration vesicle method. The effect of the precursor suspension properties, such as medium composition, pH, conductivity, and lipid mass concentration, on the charge distribution of the liposome aerosols was studied. Results and Conclusions: Results showed that the atomized liposomes have a bipolar charge distribution, and the number-fraction of charged liposome aerosols was influenced strongly by properties of the precursor solution under investigation. Liposomes synthesized in deionized water were observed to carry much higher charges than those synthesized in phosphate-buffered saline (PBS). Increasing the lipid mass concentration in the precursor suspension resulted in a decrease in the charge on the aerosols. Thus, the precursor suspension properties-composition, pH, and conductivity-can be used to control the magnitude of charge on liposome aerosols and to synthesize engineered liposome particles for the pulmonary delivery of drugs with controlled alveolar deposition and controlled delivery to alveolar macrophages.
 
Publisher MARY ANN LIEBERT INC
 
Date 2014-10-17T04:20:54Z
2014-10-17T04:20:54Z
2012
 
Type Article
 
Identifier JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 25(6)355-364
http://dx.doi.org/10.1089/jamp.2011.0967
http://dspace.library.iitb.ac.in/jspui/handle/100/15934
 
Language en