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A Tandem Enyne/Ring Closing Metathesis Approach to 4-Methylene-2-cyclohexenols: An Efficient Entry to Otteliones and Loloanolides

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Title A Tandem Enyne/Ring Closing Metathesis Approach to 4-Methylene-2-cyclohexenols: An Efficient Entry to Otteliones and Loloanolides
 
Creator BETKEKAR, VV
PANDA, S
KALIAPPAN, KP
 
Subject ENANTIOSELECTIVE TOTAL-SYNTHESIS
CATALYZED OXIDATIVE DESYMMETRIZATION
NATURAL-PRODUCT OTTELIONE
ANTITUMOR AGENT
STEREOSELECTIVE CONSTRUCTION
ABSOLUTE-CONFIGURATION
(+)-OTTELIONE-A
TUBULIN
CORE
(-)-OTTELIONE-B
 
Description A short and efficient approach to a 4-methylene-2-cyclohexenone substructure present in ottellones and loloanolides Is described. This strategy involves a tandem enyne/ring closing metathesis as the key reaction to construct this labile core unit
 
Publisher AMER CHEMICAL SOC
 
Date 2014-10-17T04:50:41Z
2014-10-17T04:50:41Z
2012
 
Type Article
 
Identifier ORGANIC LETTERS, 14(1)198-201
http://dx.doi.org/10.1021/ol2029838
http://dspace.library.iitb.ac.in/jspui/handle/100/15993
 
Language en