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Asymmetric synthesis of gamma-aminophosphonates: The bio-isosteric analogs of gamma-aminobutyric acid

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Title Asymmetric synthesis of gamma-aminophosphonates: The bio-isosteric analogs of gamma-aminobutyric acid
 
Creator BERA, K
NADKARNI, D
NAMBOOTHIRI, INN
 
Subject gamma-Aminophosphonic acid
gamma-aminobutyric acid
isosteric analogs
METABOTROPIC GLUTAMATE RECEPTORS
CONFORMATIONALLY CONSTRAINED ANALOGS
PRELIMINARY BIOLOGICAL EVALUATION
CHIRAL SULFINYL AUXILIARY
AMINO PHOSPHONIC-ACIDS
DIASTEREOSELECTIVE SYNTHESIS
ALPHA-AMINO
GROUP-III
2-AMINO-4-PHOSPHONOBUTANOIC ACIDS
ENANTIOSELECTIVE SYNTHESIS
 
Description The properties of aminophosphonates as transition state analogs of amino acids, and as antibacterial, antifungal and antiHIV agents attracted considerable attention in recent years. Although many reviews appeared in the literature covering alpha- and beta-aminophosphonates, gamma-aminophosphonates did not receive sufficient attention despite the fact that parent gamma-aminophosphonic acid and its derivatives are bio-isosteric analogs of GABA (gamma-amino butyric acid). This review provides a critical summary of the significance of gamma-aminophosphonates and various approaches to their synthesis, with particular emphasis to asymmetric versions.
 
Publisher INDIAN ACAD SCIENCES
 
Date 2014-10-17T04:55:16Z
2014-10-17T04:55:16Z
2013
 
Type Article
 
Identifier JOURNAL OF CHEMICAL SCIENCES, 125(3)443-465
http://dspace.library.iitb.ac.in/jspui/handle/100/16002
 
Language en