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Force generation and step-size fluctuations in a dynein motor

DSpace at IIT Bombay

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Title Force generation and step-size fluctuations in a dynein motor
 
Creator BAMETA, T
PADINHATEERI, R
INAMDAR, MM
 
Subject stochastic processes (theory)
molecular motors (theory)
CYTOPLASMIC DYNEIN
MOLECULAR MOTORS
SINGLE-MOLECULE
KINESIN MOLECULES
OPTICAL TWEEZERS
TRANSPORT
DYNAMICS
LOAD
 
Description Molecular motors such as dynein are known to move by taking steps of different sizes, depending on the load. Here, we develop a simple, discrete, minimal ratchet model for a motor that can take steps of sizes delta(o) and 2 delta(o) in order to provide a bare-bones description of dynein. We obtain the force-velocity curves and diffusivity for this motor for different concentrations of ATP. We also study the mechano-chemical energy transduction and thermodynamic efficiency of the motor. Further, by investigating the statistics of step sizes for the motor, we show that the average step size and fluctuation in step sizes have a non-monotonic force dependence. We develop closed-form analytical expressions for all our results, which despite the simplicity of the model give a reasonable match with the known experiments and simulations on dynein.
 
Publisher IOP PUBLISHING LTD
 
Date 2014-10-17T05:11:58Z
2014-10-17T05:11:58Z
2013
 
Type Article
 
Identifier JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT,
http://dx.doi.org/10.1088/1742-5468/2013/02/P02030
http://dspace.library.iitb.ac.in/jspui/handle/100/16035
 
Language en