Record Details

Diastereo- and enantioselective synthesis of densely functionalized cyclohexanones via double Michael addition of curcumins with nitroalkenes

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Diastereo- and enantioselective synthesis of densely functionalized cyclohexanones via double Michael addition of curcumins with nitroalkenes
 
Creator AYYAGARI, N
NAMBOOTHIRI, INN
 
Subject BIFUNCTIONAL THIOUREA
CASCADE REACTIONS
STEREOSELECTIVE-SYNTHESIS
ASYMMETRIC CATALYSIS
EFFICIENT SYNTHESIS
CONJUGATE ADDITION
DOMINO REACTIONS
ANALOGS
DERIVATIVES
ORGANOCATALYSTS
 
Description The asymmetric double Michael additions of curcumins to nitroalkenes to afford highly functionalized cyclohexanones have been carried out for the first time. A combination of a dihydrocinchonine-thiourea organocatalyst and K2CO3 was found to be the most effective in obtaining the desired cyclohexanones in good yield, diastereoselectivity and enantioselectivity. (C) 2012 Elsevier Ltd. All rights reserved.
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2014-10-17T05:28:50Z
2014-10-17T05:28:50Z
2012
 
Type Article
 
Identifier TETRAHEDRON-ASYMMETRY, 23(8)605-610
http://dx.doi.org/10.1016/j.tetasy.2012.04.011
http://dspace.library.iitb.ac.in/jspui/handle/100/16068
 
Language en