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Immobilized silver nanoparticles enhance contact killing and show highest efficacy: elucidation of the mechanism of bactericidal action of silver

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Title Immobilized silver nanoparticles enhance contact killing and show highest efficacy: elucidation of the mechanism of bactericidal action of silver
 
Creator AGNIHOTRI, S
MUKHERJI, S
MUKHERJI, S
 
Subject HOLLOW-FIBER MEMBRANE
ZEBRAFISH EMBRYOS
MULTILAYER FILMS
METAL-IONS
SURFACE
TOXICITY
WATER
NANOSILVER
RELEASE
DISSOLUTION
 
Description Antimicrobial materials with immobilized/entrapped silver nanoparticles (AgNPs) are of considerable interest. There is significant debate on the mode of bactericidal action of AgNPs, and both contact killing and/or ion mediated killing have been proposed. In this study, AgNPs were immobilized on an amine-functionalized silica surface and their bactericidal activity was studied concurrently with the silver release profile over time. This was compared with similar studies performed using colloidal AgNPs and AgCl surfaces that released Ag ions. We conclude that contact killing is the predominant bactericidal mechanism and surface immobilized nanoparticles show greater efficacy than colloidal AgNPs, as well as a higher concentration of silver ions in solution. In addition, the AgNP immobilized substrate was used multiple times with good efficacy, indicating this immobilization protocol is effective for retaining AgNPs while maintaining their disinfection potential. The antibacterial surface was found to be extremely stable in aqueous medium and no significant leaching (similar to 1.15% of total silver deposited) of the AgNPs was observed. Thus, immobilization of AgNPs on a surface may promote reuse, reduce environmental risks associated with leaching of AgNPs and enhance cost effectiveness.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2014-10-17T05:56:14Z
2014-10-17T05:56:14Z
2013
 
Type Article
 
Identifier NANOSCALE, 5(16)7328-7340
http://dx.doi.org/10.1039/c3nr00024a
http://dspace.library.iitb.ac.in/jspui/handle/100/16122
 
Language en