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Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice

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Title Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice
 
Creator ADITYA, NP
CHIMOTE, G
GUNALAN, K
BANERJEE, R
PATANKAR, S
MADHUSUDHAN, B
 
Subject Malaria
Curcuminoids
Liposomes
Combination therapy
Parasitemia
Drug delivery
IN-VIVO
LIPID NANOPARTICLES
MURINE MALARIA
THERAPY
CELLS
PHARMACOKINETICS
ANGIOGENESIS
CHEMOTHERAPY
 
Description Curcuminoids are poorly water-soluble compounds with promising antimalarial activity. To overcome some of the drawbacks of curcuminoids, we explored the potential of liposomes for the intravenous delivery of curcuminoids in a model of mouse malaria. The curcuminoids-loaded liposomes were formulated from phosphatidylcholine (soy PC) by the thin-film hydration method. Antimalarial activity of curcuminoids-loaded liposomes alone and in combination with alpha/beta arteether when administered intravenously, was evaluated in Plasmodium berghei infected mice. Animals treated with curcuminoids-loaded liposomes showed lower parasitemia and higher survival when compared to control group (no treatment). Importantly, the combination therapy of curcuminoids-loaded liposomes (40 mg/kg body wt) along with alpha/beta arteether (30 mg/kg body wt) was able to not only cure infected mice but also prevented recrudescence. These data suggest that curcuminoids-loaded liposomes may show promise as a formulation for anti-malarial therapy. (C) 2012 Elsevier Inc. All rights reserved.
 
Publisher ACADEMIC PRESS INC ELSEVIER SCIENCE
 
Date 2014-10-17T06:09:46Z
2014-10-17T06:09:46Z
2012
 
Type Article
 
Identifier EXPERIMENTAL PARASITOLOGY, 131(3)292-299
http://dx.doi.org/10.1016/j.exppara.2012.04.010
http://dspace.library.iitb.ac.in/jspui/handle/100/16148
 
Language en