Record Details

A fluorescent di-zinc(II) complex of bis-calix[4]arene conjugate as chemosensing-ensemble for the selective recognition of ATP

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title A fluorescent di-zinc(II) complex of bis-calix[4]arene conjugate as chemosensing-ensemble for the selective recognition of ATP
 
Creator MUMMIDIVARAPU, VVS
PATHAK, RK
HINGE, VK
DESSINGOU, J
RAO, CP
 
Subject bis-calix[4]arene conjugate
fluorescence switch on for Zn2+
ATP sensor
click chemistry
supramolecular chemistry
PHYSIOLOGICAL CONDITIONS
ZN2+
ZINC
SENSOR
PYROPHOSPHATE
PROBES
SWITCH
SERUM
ASSAY
CU2+
 
Description A triethylene glycol di-imine locked triazole linked bis-calix[4]arene conjugate L has been synthesised and characterised. Conjugate L exhibits high fluorescence enhancement towards Zn2+ among the 13 metal ions studied down to a lower detection limit of similar to 12 ppb. The absorption and visual colour change experiments differentiated the Zn2+ from the other metal ions studied. The isolated zinc complex, [Zn2L] has been used as a chemo-sensing ensemble for the recognition of anions based on their binding affinities towards Zn2+. [Zn2L] was found to be sensitive and selective towards phosphate-bearing species and in particular to adenosine triphosphate (ATP(2-)) among the other 20 anions studied as observed based on the changes occurred in the fluorescence intensity. The selectivity of the ATP(2-) has been shown on the basis of the changes observed in the emission and absorption spectral studies. The lowest detectable concentration for ATP(2-) with the chemosensing ensemble [Zn2L] is 348 ppb in methanol. The fluorescence quenching by the phosphate-based anions has been modelled by molecular mechanics studies and found that the anions possessing two or more phosphate moieties can only bridge between the two zinc centres, and hence those possessing only one phosphate moiety (H2PO4- and AMP(2-)) are ineffective.
 
Publisher TAYLOR & FRANCIS LTD
 
Date 2014-12-28T09:15:28Z
2014-12-28T09:15:28Z
2014
 
Type Article
 
Identifier SUPRAMOLECULAR CHEMISTRY, 26(7/8)538-546
1061-0278
1029-0478
http://dx.doi.org/10.1080/10610278.2013.868897
http://dspace.library.iitb.ac.in/jspui/handle/100/16262
 
Language English