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Spatial anisotropy and heterogeneity in contractility and adhesion distribution may contribute to cell steering during migration

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Title Spatial anisotropy and heterogeneity in contractility and adhesion distribution may contribute to cell steering during migration
 
Creator SOUMYA, SS
KOLWANKAR, S
GEORGE, E
BASU, SK
SEN, S
INAMDAR, MM
 
Subject FOCAL ADHESIONS
ADHERENT CELLS
MODEL
 
Description Transition from random to persistent cell motility requires spatiotemporal organization of the cytoskeleton and focal adhesions. The influence of these two structures on cell steering can also be gleaned from trypsin de-adhesion experiments, wherein cells exposed to trypsin round up, exhibiting a combination of rotation and translation. Here, we present a model to evaluate the contributions of contractility and bond distribution to experimentally observed de-adhesion. We show that while asymmetry in bond distribution causes only cell translation, a combination of asymmetric bond distribution and non-uniform contractility is required for translation and rotation and may guide cell migration. (C) 2014 AIP Publishing LLC.
 
Publisher AMER INST PHYSICS
 
Date 2014-12-28T09:16:01Z
2014-12-28T09:16:01Z
2014
 
Type Article
 
Identifier APPLIED PHYSICS LETTERS, 104(8)
0003-6951
1077-3118
http://dx.doi.org/10.1063/1.4866797
http://dspace.library.iitb.ac.in/jspui/handle/100/16263
 
Language English