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Carboxyl decorated Fe3O4 nanoparticles for MRI diagnosis and localized hyperthermia

DSpace at IIT Bombay

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Title Carboxyl decorated Fe3O4 nanoparticles for MRI diagnosis and localized hyperthermia
 
Creator BARICK, KC
SINGH, S
BAHADUR, D
LAWANDE, MA
PATKAR, DP
HASSAN, PA
 
Subject Nanoparticles
Fe3O4
MRI
Hyperthermia
Surface functionalization
IRON-OXIDE NANOPARTICLES
MAGNETIC HYPERTHERMIA
THERAPY
SURFACE
NANOCARRIERS
DELIVERY
AGENTS
SHELL
 
Description We report the development of carboxyl decorated iron oxide nanoparticles (CIONs) by a facile soft-chemical approach for magnetic resonance imaging (MRI) and hyperthermia applications. These superparamagnetic CIONs (similar to 10 nm) are resistant to protein adsorption under physiological medium and exhibit good colloidal stability, magnetization and cytocompatibility with cell lines. Analysis of the T-2-weighted MRI scans of CIONs in water yields a transverse relaxivity (r(2)) value of 215 mM(-1) s(-1). The good colloidal stability and high r(2) value make these CIONs as promising candidates for high-efficiency T-2 contrast agent in MRI. Further, these biocompatible nanoparticles show excellent self-heating efficacy under external AC magnetic field (AMF). The infrared thermal imaging confirmed the localized heating of CIONs under AMF. Thus, these carboxyl decorated Fe3O4 nanoparticles can be used as a contrast agent in MRI as well as localized heat activated killing of cancer cells. Furthermore, the active functional groups (-COOH) present on the surface of Fe3O4 nanoparticles can be accessible for routine conjugation of biomolecules/drugs through well-developed bioconjugation chemistry. (C) 2013 Elsevier Inc. All rights reserved.
 
Publisher ACADEMIC PRESS INC ELSEVIER SCIENCE
 
Date 2014-12-28T11:11:23Z
2014-12-28T11:11:23Z
2014
 
Type Article
 
Identifier JOURNAL OF COLLOID AND INTERFACE SCIENCE, 418120-125
0021-9797
1095-7103
http://dx.doi.org/10.1016/j.jcis.2013.11.076
http://dspace.library.iitb.ac.in/jspui/handle/100/16325
 
Language English