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Interaction of homologous series of amino acids with sarcosine in presence of denaturant: Volumetric and calorimetric approach

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Title Interaction of homologous series of amino acids with sarcosine in presence of denaturant: Volumetric and calorimetric approach
 
Creator KUMAR, N
KISHORE, N
 
Subject PARTIAL MOLAR VOLUMES
TRIMETHYLAMINE N-OXIDE
PROTEIN STABILIZATION
ORGANIC-COMPOUNDS
UREA
WATER
OSMOLYTES
COMPRESSIBILITY
THERMODYNAMICS
COUNTERACTION
 
Description Densities (rho) and speeds of sound (u) of homologous serious of five amino acids: glycine, L-alanine, DL-alpha-amino- n-butyric acid, L-valine, and L-leucine were measured in aqueous 1.0 mol . dm(-3) sarcosine and (1.0 mol . dm(-3) sarcosine + 1.0 mol . dm(-3) urea) solutions. The values of corresponding apparent molar volume (V-2,V-phi), apparent molar compressibility (K-S,K-2,K-phi) were calculated from the density and speed of sound data at T 298: 15 K. Enthalpies of dilution (q) of amino acids from water to 1.0 mol . dm(-3) sarcosine and (1.0 mol . dm(-3) sarcosine + 1.0 mol . dm(-3) urea) solution were also measured. By linear regression fitting, the values of standard partial molar volume (V-2,m(0)) and partial molar compressibility (K-S,2,m(0)) and standard enthalpy of dilution (DtrDdilH0) were determined. The contribution of zwitterionic and hydrophobic groups of amino acids to V-2,m(0) were also calculated from linear regression fitting of V-2,V-phi values. The different cosolvent interactions were interpreted on the basis of cosphere overlap model. The results suggest the dominance of ionic-ionic and hydrophilic-ionic group interactions over hydrophobic- hydrophilic and ionic-hydrophobic interactions. (C) 2013 Elsevier Ltd. All rights reserved.
 
Publisher ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
 
Date 2014-12-28T11:13:23Z
2014-12-28T11:13:23Z
2014
 
Type Article
 
Identifier JOURNAL OF CHEMICAL THERMODYNAMICS, 68244-252
0021-9614
1096-3626
http://dx.doi.org/10.1016/j.jct.2013.09.009
http://dspace.library.iitb.ac.in/jspui/handle/100/16329
 
Language English