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Characterization of cost with respect to nutritional upshift in the media composition along with sublethal doses of transcriptional and translational inhibitor

DSpace at IIT Bombay

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Title Characterization of cost with respect to nutritional upshift in the media composition along with sublethal doses of transcriptional and translational inhibitor
 
Creator MALAKAR, P
 
Subject Upshift
Rifampicin
Chloramphenicol
Cost process
Escherichia coli
ESCHERICHIA-COLI
GENE-EXPRESSION
GROWTH
PROTEINS
OPERON
CONSEQUENCES
NETWORKS
BACTERIA
PERMEASE
 
Description Expression of unnecessary proteins is known to reduce the growth rate of Escherichia coli. This reduction in growth rate, due to the diversion of cellular resources from making essential proteins, is called cost. Cellular resources depend upon the macromolecular content of the cell. Cost phenomenon lies in the process of transcription and translation. The effect of an upshift in the nutritional content of the medium on the cost process of natural lac proteins is not looked upon. Which process of gene expression, transcription, or translation is more important for the cost process is not clear. The current study indicated that cost process is not associated with the upshift mechanism. Cost process was not observed in presence of rifampicin but was detected in existence of chloramphenicol. The current study will help in better understanding of the cost process.
 
Publisher SPRINGER
 
Date 2014-12-28T11:47:29Z
2014-12-28T11:47:29Z
2014
 
Type Article
 
Identifier ARCHIVES OF MICROBIOLOGY, 196(4)289-294
0302-8933
1432-072X
http://dx.doi.org/10.1007/s00203-014-0967-1
http://dspace.library.iitb.ac.in/jspui/handle/100/16397
 
Language English