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Ce3+ sensitized GdPO4:Tb3+ with iron oxide nanoparticles: a potential biphasic system for cancer theranostics

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Title Ce3+ sensitized GdPO4:Tb3+ with iron oxide nanoparticles: a potential biphasic system for cancer theranostics
 
Creator SAHU, NK
SINGH, NS
PRADHAN, L
BAHADUR, D
 
Subject UP-CONVERSION LUMINESCENT
TARGETED DRUG-DELIVERY
INORGANIC NANOPARTICLES
FE3O4 NANOPARTICLES
CONTROLLED-RELEASE
ENERGY-TRANSFER
THERAPY
NANORODS
NANOCOMPOSITES
NANOCARRIERS
 
Description We report a biphasic system (BPS) consisting of PEGylated Tb3+-doped GdPO4 nanorice sensitized with Ce3+ (PEG-NRs) and glutamic acid coated iron oxide nanoparticles (IONPs) with multifunctional capabilities. The mesoporous PEG-NRs exhibit green light luminescence properties and a high degree of aqueous stability. Their drug loading and release capacities were investigated for anti-cancer chemo doxorubicin (DOX). Their mesoporous nature and availability of plenty of negatively charged functional groups (-COO-) on the surface of PEG-NRs facilitate approximately 94 wt% DOX loading. In vitro studies carried out for PEG-NRs and their biphasic integrated system with iron oxide using HeLa and MCF-7 cell lines demonstrated their cell killing efficacy. The green luminescence observed under confocal laser scanning microscopy (CLSM) confirms the cellular uptake of PEG-NRs by HeLa cell lines and their accumulation in the cytoplasm. Approximately 50-55% of HeLa and MCF-7 cell death was observed after 24 h of incubation with DOX loaded BPS (2 mg IONPs and 0.25 mg PEG-NRs + DOX), which further increased to about 90% when exposed to an AC magnetic field (ACMF) for 25 min. Our findings demonstrate that the therapeutic efficacy of BPS loaded with DOX could be a powerful multimodal system for imaging and synergistic chemo-thermal cancer therapy.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2014-12-28T12:18:12Z
2014-12-28T12:18:12Z
2014
 
Type Article
 
Identifier DALTON TRANSACTIONS, 43(30)11728-11738
1477-9226
1477-9234
http://dx.doi.org/10.1039/c4dt00792a
http://dspace.library.iitb.ac.in/jspui/handle/100/16484
 
Language English