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Gold Nanocages as Effective Photothermal Transducers in Killing Highly Tumorigenic Cancer Cells

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Title Gold Nanocages as Effective Photothermal Transducers in Killing Highly Tumorigenic Cancer Cells
 
Creator RENGAN, AK
KUNDU, G
BANERJEE, R
SRIVASTAVA, R
 
Subject cancer nanotechnology
gold nanocages
gold nanoshells
nanomedicine
photothermal therapy
NEAR-INFRARED LIGHT
NANOSHELLS
NANORODS
THERAPY
NANOSTRUCTURES
NANOPARTICLES
POLYMERS
RELEASE
 
Description Numerous gold nanostructures have the potential for photothermal therapy in cancers. Here, gold nanocages and gold nanoshells are synthesized, the sizes of which are fine-tuned for a response at 750 nm wavelength. Their photothermal therapeutic efficiency is compared at gold concentration of 100 lg mL(-1) using a near-infrared laser (750 nm). The biocompatibility for varying concentrations of gold (1 to 100 lg mL(-1)) is performed in a normal cell line and laser-mediated cell cytotoxicity for varying time intervals (7.5 and 10 min) is carried out in breast cancer cells. This study shows that when analyzed under similar conditions, the gold nanocages show better biocompatibility and are more efficient in near-infrared absorption and photothermal conversion in comparison with conventional gold nanoshells. When subjected to photothermal laser ablation of breast cancer cell line for 7.5 min and 10 min, the nanocages are able to induce 62.92 +/- 3.25% and 96.41 +/- 3.04% reduction in cell viability, respectively, in comparison to nanoshells, in which a 43.35 +/- 1.91% and 79.89 +/- 4.74% reduction in cell viability is observed. The current study shows that the gold nanocages can outperform gold nanoshells and effectively kill cancer cells without any significant cytotoxic effect on normal cells.
 
Publisher WILEY-V C H VERLAG GMBH
 
Date 2014-12-28T12:49:29Z
2014-12-28T12:49:29Z
2014
 
Type Article
 
Identifier PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 31(3)398-405
0934-0866
1521-4117
http://dx.doi.org/10.1002/ppsc.201300173
http://dspace.library.iitb.ac.in/jspui/handle/100/16603
 
Language English