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First Synthesis of Bacillus cereus Ch HF-PS Cell Wall Trisaccharide Repeating Unit

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Field Value
 
Title First Synthesis of Bacillus cereus Ch HF-PS Cell Wall Trisaccharide Repeating Unit
 
Creator PODILAPU, AR
KULKARNI, SS
 
Subject SUGAR BUILDING-BLOCKS
RARE-SUGAR
BACTERIAL
 
Description The first total synthesis of Ch HF-PS, a cell wall trisaccharide repeating unit of B. cereus, is reported. The synthetic trisaccharide is appended with an aminopropyl linker at the reducing end to allow for conjugation to proteins and microarrays. The convergent synthesis involves transformation of D-mannose into an orthogonally protected rare AAT sugar building block, two consecutive alpha-stereoselective glycosylations, beta-selective attachment of the linker by solvent participation, and amide bond formation, as key steps.
 
Publisher AMER CHEMICAL SOC
 
Date 2014-12-28T12:51:04Z
2014-12-28T12:51:04Z
2014
 
Type Article
 
Identifier ORGANIC LETTERS, 16(16)4336-4339
1523-7060
1523-7052
http://dx.doi.org/10.1021/ol5021527
http://dspace.library.iitb.ac.in/jspui/handle/100/16609
 
Language English