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Equilibrium Morphologies and Force Extension Behavior for Polymers with Hydrophobic Patches: Role of Quenched Disorder

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Title Equilibrium Morphologies and Force Extension Behavior for Polymers with Hydrophobic Patches: Role of Quenched Disorder
 
Creator MISHRA, A
PANWAR, AS
CHAKRABARTI, B
 
Subject globule-coil transition
hydrophobicity
molecular simulations
quenched disorder
semiflexible polymers
DEPENDENT SEQUENCE DESIGN
STATISTICAL-MECHANICS
RANDOM HETEROPOLYMERS
AB COPOLYMERS
DYNAMICS
PROTEINS
COLLAPSE
MODEL
DNA
 
Description Equilibrium morphologies and mechanical properties of copolymers with hydrophobic segments are explored using Langevin dynamics simulations. The interplay between different length scales, namely, persistence length p, and disorder correlation length p, in addition to the fraction of hydrophobic patches f, determines the equilibrium morphology and in turn their mechanical response. Globular and coil phases for flexible chains and core-shell and looped morphologies for semi-flexible ones are reported. Consequently, a force induced globule-coil transition for flexible chains is observed for all disorder realizations, with p dictating the force vs. extension curves. Semi-flexible chains with same p and f but different p, show different sequences of force-induced conformational transitions on account of their differing equilibrium conformations.
 
Publisher WILEY-V C H VERLAG GMBH
 
Date 2014-12-28T12:52:08Z
2014-12-28T12:52:08Z
2014
 
Type Article
 
Identifier MACROMOLECULAR THEORY AND SIMULATIONS, 23(4)266-278
1022-1344
1521-3919
http://dx.doi.org/10.1002/mats.201300154
http://dspace.library.iitb.ac.in/jspui/handle/100/16612
 
Language English