Record Details

Meta-Selective Arene C-H Bond Olefination of Arylacetic Acid Using a Nitrile-Based Directing Group

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Field Value
 
Title Meta-Selective Arene C-H Bond Olefination of Arylacetic Acid Using a Nitrile-Based Directing Group
 
Creator BERA, M
MODAK, A
PATRA, T
MAJI, A
MAITI, D
 
Subject CATALYZED DIRECT ARYLATION
CARBON-HYDROGEN BONDS
FUNCTIONALIZATION LOGIC
NATURAL-PRODUCTS
ACTIVATION
PALLADIUM
BORYLATION
TEMPLATE
CONSTRUCTION
REACTIVITY
 
Description A nitrile-based template attached with a phenylacetic acid framework promoted meta-selective CH bond olefination. This palladium-catalyzed protocol is applicable to a wide range of substituted phenylacetic acids and tolerates a variety of functional groups. The versatility of this operationally simple method has been demonstrated through drug diversification.
 
Publisher AMER CHEMICAL SOC
 
Date 2014-12-28T12:56:45Z
2014-12-28T12:56:45Z
2014
 
Type Article
 
Identifier ORGANIC LETTERS, 16(21)5760-5763
1523-7060
1523-7052
http://dx.doi.org/10.1021/ol502823c
http://dspace.library.iitb.ac.in/jspui/handle/100/16628
 
Language English