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Biphasic magnetic nanoparticles-nanovesicle hybrids for chemotherapy and self-controlled hyperthermia

DSpace at IIT Bombay

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Title Biphasic magnetic nanoparticles-nanovesicle hybrids for chemotherapy and self-controlled hyperthermia
 
Creator GOGOI, M
SARMA, HD
BAHADUR, D
BANERJEE, R
 
Subject biphasic suspension
cancer
chemotherapy
magnetic nanovesicle
self-controlled hyperthermia
POLY(ETHYLENE GLYCOL)
CATIONIC LIPOSOMES
TUMOR VASCULATURE
IN-VIVO
DRUG-DELIVERY
CELL-DEATH
THERAPY
PACLITAXEL
CYTOTOXICITY
CHOLESTEROL
 
Description Aim: The aim was to develop magnetic nanovesicles for chemotherapy and self-controlled hyperthermia that prevent overheating of tissues. Materials & methods: Magnetic nanovesicles containing paclitaxel and a dextran-coated biphasic suspension of La0.75Sr0.25MnO3 and Fe3O4 nanoparticles (magnetic nanoparticles) were developed. Results: Encapsulation efficiencies of magnetic nanoparticles and paclitaxel were 67 +/- 5 and 83 +/- 3%, respectively. Sequential release performed at 37 degrees C for 1 h followed by 44 degrees C for another 1 h (as expected for intratumoral injection), showed a cumulative release of 6.6% (109.6 mu g), which was above the IC50 of the drug. In an alternating current magnetic field, the temperature remained controlled at 44 degrees C and a synergistic cytotoxicity of paclitaxel and hyperthermia was observed in MCF-7 cells. Conclusion: Magnetic nanovesicles containing biphasic suspensions La0.75Sr0.25MnO3 and Fe3O4 nanoparticles encapsulating paclitaxel have potential for combined self-controlled hyperthermia and chemotherapy.
 
Publisher FUTURE MEDICINE LTD
 
Date 2014-12-28T15:04:24Z
2014-12-28T15:04:24Z
2014
 
Type Article
 
Identifier NANOMEDICINE, 9(7)955-970
1743-5889
1748-6963
http://dx.doi.org/10.2217/NNM.13.90
http://dspace.library.iitb.ac.in/jspui/handle/100/16825
 
Language English