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Diffusion in an elastic medium: A model for macromolecule transport across the nuclear pore complex

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Title Diffusion in an elastic medium: A model for macromolecule transport across the nuclear pore complex
 
Creator CHAKRABARTI, R
DEBNATH, A
SEBASTIAN, KL
 
Subject Nuclear pore complex
Diffusion of macromolecules
Brush vs gel picture of nuclear pore complex
Enhancement in diffusion
NUCLEOCYTOPLASMIC TRANSPORT
IMPORTIN-BETA
SEMIFLEXIBLE POLYMERS
PROTEIN-TRANSPORT
CHAIN MOLECULE
KINK MOTION
DYNAMICS
NUCLEOPORINS
TRANSLOCATION
PERMEABILITY
 
Description Nuclear pore complexes (NPCs) are very selective filters that sit on the membrane of the nucleus and monitor the transport between the cytoplasm and the nucleoplasm. For the central plug of NPC two models have been suggested in the literature. The first suggests that the plug is a reversible hydrogel while the other suggests that it is a polymer brush. Here we propose a model for the transport of a protein through the plug, which is general enough to cover both the models. The protein stretches the plug and creates a local deformation, which together with the protein, we refer to as the bubble. We start with the free energy for creation of the bubble and consider its motion within the plug. The relevant coordinate is the center of the bubble which executes random walk. We find that for faster relaxation of the gel, the diffusion of the bubble is greater. (C) 2014 Elsevier-B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE BV
 
Date 2014-12-28T16:26:41Z
2014-12-28T16:26:41Z
2014
 
Type Article
 
Identifier PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 40465-78
0378-4371
1873-2119
http://dx.doi.org/10.1016/j.physa.2014.02.059
http://dspace.library.iitb.ac.in/jspui/handle/100/16881
 
Language English