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Electropolymerization of bromothymol blue on carbon paste electrode bulk modified with oxidized multiwall carbon nanotubes and its application in amperometric sensing of epinephrine in pharmaceutical and biological samples

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Title Electropolymerization of bromothymol blue on carbon paste electrode bulk modified with oxidized multiwall carbon nanotubes and its application in amperometric sensing of epinephrine in pharmaceutical and biological samples
 
Creator PRADHAN, P
MASCARENHAS, RJ
THOMAS, T
NAMBOOTHIRI, INN
D'SOUZA, OJ
MEKHALIF, Z
 
Subject Composite electrode
Epinephrine
Amperometry
Electropolymerization
Bromothymol blue
Multi-walled carbon nanotubes
FILM-MODIFIED ELECTRODE
ASCORBIC-ACID
URIC-ACID
SELECTIVE DETERMINATION
ELECTROCHEMICAL DETERMINATION
ELECTROANALYTICAL CHEMISTRY
ELECTROCATALYTIC OXIDATION
GOLD NANOPARTICLES
HUMAN SERUM
DOPAMINE
 
Description A composite electrode for an amperometric detection of epinephrine (EP) has been developed by electropolymerizing bromothymol blue (BTB) on carbon paste electrode (CPE) bulk modified with multi-walled carbon nanotubes (MWCNTs). The field-emission scanning electron microscopy and the energy dispersive X-ray analysis (EDX) confirm the formation of poly(bromothymol blue). A possible mechanism of electropolymerization of BTB has been proposed. The electropolymerization of BTB on the surface of CPE involves much less energy as compared to that of glassy carbon surface. The modification enhanced the current sensitivity of EP by 5.5 times as compared to the bare CPE. The electrocheinical impedance spectroscopy (EIS) studies revealed a least charge transfer resistance (R-ct) for the modified electrode. The sensor showed an optimum current response at physiological pH and the response was linear for the concentration of EP in the ranges 0.8-9.0 mu M and 10.0-100 mu M, with a detection limit of 8 x 10(-7) M. The amperometric response of EP remains unaltered even in the presence of 50-fold excess of uric acid, ascorbic acid and 100-fold excess of L-Tryptophan, L-Tyrosine, L-Cysteine and Nicotinamide adenine dinucleotide. This sensor has shown stability, reproducibility, anti fouling effects and was successfully applied for the determination of EP in blood serum and adrenaline injection. (C) 2014 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE SA
 
Date 2014-12-28T16:40:21Z
2014-12-28T16:40:21Z
2014
 
Type Article
 
Identifier JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 73230-37
1572-6657
1873-2569
http://dx.doi.org/10.1016/j.jelechem.2014.08.023
http://dspace.library.iitb.ac.in/jspui/handle/100/16908
 
Language English