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Enhanced specific absorption rate in silanol functionalized Fe3O4 core-shell nanoparticles: Study of Fe leaching in Fe3O4 and hyperthermia in L929 and HeLa cells

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Title Enhanced specific absorption rate in silanol functionalized Fe3O4 core-shell nanoparticles: Study of Fe leaching in Fe3O4 and hyperthermia in L929 and HeLa cells
 
Creator MAJEED, J
PRADHAN, L
NINGTHOUJAM, RS
VATSA, RK
BAHADUR, D
TYAGI, AK
 
Subject Magnetic nanoparticles
Cytotoxicity
Leaching
Silica coating
Hyperthermia
MAGNETIC NANOPARTICLES
THERMAL THERAPY
OLEIC-ACID
SIZE
NANOCOMPOSITES
IRON
SEPARATION
PARTICLES
PROTEINS
AGENTS
 
Description Core-shell Fe3O4-SiO2 magnetic nanoparticles (MNPs) have been synthesized using a simple synthesis procedure at different temperatures. These MNPs are used to investigate the effect of surface coating on specific absorption rate (SAR) under alternating magnetic field. The temperature achieved by silica coated Fe3O4 is higher than that by uncoated MNPs (Fe3O4). This can be attributed to extent of increase in Brownian motion for silica coated MNPs. The sample prepared at optimized temperature of 80 degrees C shows the highest SAR value of 111 W/g. It is found that SAR value decreases with increase in shell thickness. The chemical stability of these samples is analyzed by leaching experiments at pH 2-7. The silica coated samples are stable up to 7 days even at pH 2. Biocompatibility of the MNPs is evaluated in vitro by assessing their cytotoxicity on L929 and human cervical cancer cells (HeLa cells) using sulforhodamine-B assay. Their hyperthermic killing ability is also evaluated in HeLa cells using the same method. Cells treated with MNPs along with induction heating show decrease in viability as compared to that without induction heating. Further, cell death is found to be similar to 55% more in cells treated with silica coated MNPs under induction heating as compared to untreated control. These results establish the efficacy of Fe3O4-SiO2 prepared at 80 degrees C in killing of tumor cells by cellular hyperthermia. (C) 2014 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE BV
 
Date 2014-12-28T17:00:24Z
2014-12-28T17:00:24Z
2014
 
Type Article
 
Identifier COLLOIDS AND SURFACES B-BIOINTERFACES, 122396-403
0927-7765
1873-4367
http://dx.doi.org/10.1016/j.colsurfb.2014.07.019
http://dspace.library.iitb.ac.in/jspui/handle/100/16948
 
Language English