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The structure of dynamic GPCR signaling networks

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Title The structure of dynamic GPCR signaling networks
 
Creator O'NEILL, PR
GIRI, L
KARUNARATHNE, WKA
PATEL, AK
VENKATESH, KV
GAUTAM, N
 
Subject TO-CELL VARIABILITY
EUKARYOTIC CHEMOTAXIS
MICROFLUIDIC DEVICES
LIVING CELLS
PROTEIN
RECEPTOR
OSCILLATIONS
ADAPTATION
INITIATION
GRADIENTS
 
Description G-protein-coupled receptors (GPCRs) stimulate signaling networks that control a variety of critical physiological processes. Static information on the map of interacting signaling molecules at the basis of many cellular processes exists, but little is known about the dynamic operation of these networks. Here we focus on two questions. First, Is the network architecture underlying GPCR-activated cellular processes unique in comparison with others such as transcriptional networks? We discuss how spatially localized GPCR signaling requires uniquely organized networks to execute polarized cell responses. Second, What approaches overcome challenges in deciphering spatiotemporally dynamic networks that govern cell behavior? We focus on recently developed microfluidic and optical approaches that allow GPCR signaling pathways to be triggered and perturbed with spatially and temporally variant input while simultaneously visualizing molecular and cellular responses. When integrated with mathematical modeling, these approaches can help identify design principles that govern cell responses to extracellular signals. We outline why optical approaches that allow the behavior of a selected cell to be orchestrated continually are particularly well suited for probing network organization in single cells. (C) 2013 Wiley Periodicals, Inc.
 
Publisher WILEY-BLACKWELL
 
Date 2014-12-28T18:09:32Z
2014-12-28T18:09:32Z
2014
 
Type Article
 
Identifier WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 6(1)115-123
1939-5094
1939-005X
http://dx.doi.org/10.1002/wsbm.1249
http://dspace.library.iitb.ac.in/jspui/handle/100/17071
 
Language English