Record Details

Multi-scale strategy to eradicate Pseudomonas aeruginosa on surfaces using solid lipid nanoparticles loaded with free fatty acids

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Multi-scale strategy to eradicate Pseudomonas aeruginosa on surfaces using solid lipid nanoparticles loaded with free fatty acids
 
Creator TAYLOR, EN
KUMMER, KM
DYONDI, D
WEBSTER, TJ
BANERJEE, R
 
Subject RESISTANT STAPHYLOCOCCUS-AUREUS
NANOPHASE CERAMICS
INCREASED OSTEOBLAST
BACTERIAL BIOFILMS
INFECTIONS
TITANIUM
GROWTH
MECHANISMS
NANOTECHNOLOGY
REGENERATION
 
Description Infections are both frequent and costly in hospitals around the world, leading to longer hospital stays, overuse of antibiotics, and excessive costs to the healthcare system. Moreover, antibiotic resistant organisms, such as Pseudomonas aeruginosa are increasing in frequency, leading to 1.7 million infections per year in USA hospitals, and 99 000 deaths, both due to the evolution of antibiotic resistance and the formation of biofilms on medical devices. In particular, respiratory infections are costly, deadly to 4.5 million persons per year worldwide, and can spread to the lungs through the placement of endotracheal tubing. In this study, towards a reduction in infections, solid lipid nanoparticles were formulated from free fatty acids, or natural lipophilic constituents found in tissues of the body. A strategy was developed to target infections by producing coatings made of non-toxic chemistries lauric acid and oleic acid delivered by core-shell solid lipid nanoparticles that act against bacteria by multiple mechanisms at the nanoscale, including disruption of bacteria leading to DNA release, and reducing the adhesion of dead bacteria to similar to 1%. This is the first such study to explore an anti-infection surface relying on these multi-tier strategies at the nanoscale.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2014-12-29T04:42:26Z
2014-12-29T04:42:26Z
2014
 
Type Article
 
Identifier NANOSCALE, 6(2)825-832
2040-3364
2040-3372
http://dx.doi.org/10.1039/c3nr04270g
http://dspace.library.iitb.ac.in/jspui/handle/100/17104
 
Language English