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Ring-Closing Metathesis Enabled Efficient Synthesis of gamma-Butenolide Antifungal Agent (-)-Incrustoporin and its Analogues

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Title Ring-Closing Metathesis Enabled Efficient Synthesis of gamma-Butenolide Antifungal Agent (-)-Incrustoporin and its Analogues
 
Creator FERNANDES, RA
PATIL, PH
CHOWDHURY, AK
 
Subject incrustoporin
kinetic resolution
natural products
ring-closing metathesis
total synthesis
INCRUSTOPORIA-CARNEOLA
CONCISE SYNTHESIS
ALDEHYDES
LACTONES
ACIDS
 
Description An efficient synthesis of the antifungal agent (-)-incrustoporin and analogues based on ring-closing metathesis (RCM) is described. The ready availability of various allyl alcohols through the Sharpless kinetic resolution and esterification with a variety of substituted aryl acetic acids, followed by -methylenation and final RCM to get the targets makes this explored strategy suitable for rapid development of analogues.
 
Publisher WILEY-V C H VERLAG GMBH
 
Date 2014-12-29T04:54:12Z
2014-12-29T04:54:12Z
2014
 
Type Article
 
Identifier ASIAN JOURNAL OF ORGANIC CHEMISTRY, 3(1)58-62
2193-5807
2193-5815
http://dx.doi.org/10.1002/ajoc.201300216
http://dspace.library.iitb.ac.in/jspui/handle/100/17127
 
Language English