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Enhancing Cubosome Functionality by Coating with a Single Layer of Poly-epsilon-lysine

DSpace at IIT Bombay

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Title Enhancing Cubosome Functionality by Coating with a Single Layer of Poly-epsilon-lysine
 
Creator DESHPANDE, S
VENUGOPAL, E
RAMAGIRI, S
BELLARE, JR
KUMARASWAMY, G
SINGH, N
 
Subject bioconjugation
cubosomes
drug delivery vehicle
dual loading
theranostics
LIQUID-CRYSTALLINE DISPERSIONS
DRUG-DELIVERY-SYSTEM
IN-VITRO
SUBMICRON PARTICLES
NANOPARTICLES
PHASES
WATER
VIVO
CYTOTOXICITY
EFFICIENCY
 
Description We report the preparation and characterization of monoolein cubosomes that can be easily surface modified through adsorption of a single layer of cationic poly-epsilon-lysine. Poly-epsilon-lysine coated cubosomes show remarkable stability in serum solution, are nontoxic and, are readily internalized by HeLa cells. The poly-epsilon-lysine coating provides chemical handles for further bioconjugation of the cubosome surface. We also demonstrate that the initial release rate of a hydrophilic drug, Naproxen sodium, from the cubosomes is retarded with just a single layer of polymer. Interestingly, cubosomes loaded with Naproxen sodium, recently shown to have anticancer properties, cause more apoptosis in HeLa cells when compared to free unencapsulated drug.
 
Publisher AMER CHEMICAL SOC
 
Date 2014-12-29T05:33:43Z
2014-12-29T05:33:43Z
2014
 
Type Article
 
Identifier ACS APPLIED MATERIALS & INTERFACES, 6(19)17126-17133
1944-8244
http://dx.doi.org/10.1021/am5047872
http://dspace.library.iitb.ac.in/jspui/handle/100/17204
 
Language English