Record Details

Antimicrobial Peptide CRAMP (16-33) Stalls Bacterial Cytokinesis by Inhibiting FtsZ Assembly

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Title Antimicrobial Peptide CRAMP (16-33) Stalls Bacterial Cytokinesis by Inhibiting FtsZ Assembly
 
Creator RAY, S
DHAKED, HPS
PANDA, D
 
Subject CELL-DIVISION
BACILLUS-SUBTILIS
MEMBRANE
INSIGHTS
 
Description A cathelin-related antimicrobial peptide (CRAMP) of 37 amino acid residues is thought to regulate innate immunity and provide a host defense mechanism in mammals. Here, a part of the CRAMP peptide, CRAMP (16-33) (GEKLKKIGQKIKNFFQKL), was found to bind to FtsZ and to inhibit the assembly and GTPase activity of FtsZ in vitro. A computational analysis indicated that CRAMP (16-33) binds in the cavity of the T7 loop of FtsZ. Both hydrophobic and ionic interactions were involved in the binding interactions. Further, CRAMP (16-33) inhibited the formation of the FtsZ ring in bacteria, indicating that it inhibited bacterial cell division by inhibiting FtsZ assembly.
 
Publisher AMER CHEMICAL SOC
 
Date 2014-12-29T05:36:14Z
2014-12-29T05:36:14Z
2014
 
Type Article
 
Identifier BIOCHEMISTRY, 53(41)6426-6429
0006-2960
http://dx.doi.org/10.1021/bi501115p
http://dspace.library.iitb.ac.in/jspui/handle/100/17209
 
Language English