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Synthesis of Sub-100-nm Liposomes via Hydration in a Packed Bed of Colloidal Particles

DSpace at IIT Bombay

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Field Value
 
Title Synthesis of Sub-100-nm Liposomes via Hydration in a Packed Bed of Colloidal Particles
 
Creator SUNDAR, SK
TIRUMKUDULU, MS
 
Subject LARGE UNILAMELLAR VESICLES
RAPID EXTRUSION PROCEDURE
SIZE DISTRIBUTION
MEMBRANES
VOLUME
 
Description Drug delivery using liposomal carriers for targeting the afflicted areas of the host has attracted significant interest in the scientific community. While traditional liposome preparation techniques result in polydisperse suspension, postprocessing steps such as extrusion or filtering is required to obtain monodisperse liposomes in the sub-100-nm size range. Here, we describe a novel technique to synthesize monodisperse liposomes in the sub-100-nm size range using a packed bed of colloidal particles which could also be used to simultaneously encapsulate a drug. The methodology involves drying lipids dispersed in an organic solvent in a capillary packed with colloidal particles, which upon hydration with an aqueous buffer containing a drug leads to liposome formation with simultaneous encapsulation of the drug. Our experiments show that the size of the liposome is independent of the particle size or the pore size. The robustness of the process and the extremely tight control on the liposome size range make it amenable to point-of-care therapeutics involving liposomal drug delivery systems. We conclude with a discussion on the possible mechanisms for narrow size distribution of liposomes.
 
Publisher AMER CHEMICAL SOC
 
Date 2014-12-29T05:36:44Z
2014-12-29T05:36:44Z
2014
 
Type Article
 
Identifier INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 53(1)198-205
0888-5885
http://dx.doi.org/10.1021/ie402567p
http://dspace.library.iitb.ac.in/jspui/handle/100/17210
 
Language English