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Synthesis and evaluation of 2-heteroaryl and 2,3-diheteroaryl-1,4-naphthoquinones that potently induce apoptosis in cancer cells

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Title Synthesis and evaluation of 2-heteroaryl and 2,3-diheteroaryl-1,4-naphthoquinones that potently induce apoptosis in cancer cells
 
Creator TANDON, VK
MAURYA, HK
KUMAR, S
RASHID, A
PANDA, D
 
Subject BIOLOGICAL EVALUATION
1,4-NAPHTHOQUINONE DERIVATIVES
ANTIBACTERIAL AGENTS
NUCLEOPHILIC-SUBSTITUTION
KINETIC STABILIZATION
MICROTUBULE DYNAMICS
AQUEOUS SUSPENSION
ANTICANCER AGENTS
ANTIFUNGAL AGENTS
ORGANIC-REACTIONS
 
Description This article describes the preparation of 2-heteroaryl and 2,3-diheteroaryl-1,4-naphthoquinones by an environmentally benign short synthetic route with the goal of finding 1,4-naphthoquinone derivatives that induce apoptosis in cancer cells. We have identified three most active naphthoquinones 10, 12 and 15 that potently induce apoptosis in human cervical carcinoma (HeLa) cells. One of these three compounds perturbed both microtubule and actin filaments.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2014-12-29T06:04:48Z
2014-12-29T06:04:48Z
2014
 
Type Article
 
Identifier RSC ADVANCES, 4(24)12441-12447
2046-2069
http://dx.doi.org/10.1039/c3ra47720g
http://dspace.library.iitb.ac.in/jspui/handle/100/17265
 
Language English