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A facile chemoselective deprotection of aryl silyl ethers using sodium hydride/DMF and in situ protection of phenol with various groups

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Title A facile chemoselective deprotection of aryl silyl ethers using sodium hydride/DMF and in situ protection of phenol with various groups
 
Creator FERNANDES, RA
GHOLAP, SP
MULAY, SV
 
Subject TERT-BUTYLDIMETHYLSILYL ETHERS
SELECTIVE DEPROTECTION
HYDROXYL-GROUPS
DESILYLATION
MILD
EFFICIENT
ALKYL
BASE
 
Description An efficient method for the selective removal of aryl silyl protection using NaH in DMF solvent is developed. The method is rapid, operationally simple and can be carried out at room temperature. Excellent chemoselectivity and high yields of phenol products are other advantages of this method. A one-pot desilylation and reprotection as aryl alkyl ethers and esters has also been demonstrated.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2014-12-29T06:08:25Z
2014-12-29T06:08:25Z
2014
 
Type Article
 
Identifier RSC ADVANCES, 4(32)16438-16443
2046-2069
http://dx.doi.org/10.1039/c4ra00842a
http://dspace.library.iitb.ac.in/jspui/handle/100/17272
 
Language English