ICAR Research Data Repository for Knowledge Management
Total synthesis of MECA-79
DSpace at IIT Bombay
View Archive Info| Field | Value | |
| Title |
Total synthesis of MECA-79
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| Creator |
BEHERA, A
EMMADI, M KULKARNI, SS |
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| Subject |
GLYCOPEPTIDE ANTIGENS
ANTICANCER VACCINES BUILDING-BLOCKS D-GLUCOSAMINE L-SELECTIN CARBOHYDRATE THIOGLYCOSIDES GLYCOSYLATION LIGAND |
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| Description |
The MECA-79 antigen is a sulfated mucin type core-1 extended O-glycan which is a potential anti-inflammatory agent. Herein we report a total synthesis of MECA-79 via a convergent [2 + 2] glycosylation route. The synthesis relies on efficient transformation of D-glucosamine into the orthogonally protected Tn antigen derivative and its elaboration into the TF antigen en route to MECA-79.
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| Publisher |
ROYAL SOC CHEMISTRY
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| Date |
2014-12-29T06:15:34Z
2014-12-29T06:15:34Z 2014 |
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| Type |
Article
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| Identifier |
RSC ADVANCES, 4(102)58573-58580
2046-2069 http://dx.doi.org/10.1039/c4ra12631a http://dspace.library.iitb.ac.in/jspui/handle/100/17286 |
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| Language |
English
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