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Collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones

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Title Collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones
 
Creator DAS, D
DAS, D
PADINHATEERI, R
 
Subject non-equilibrium chemical switching
dynamics of biofilaments
collective force generation
actin and microtubules
DYNAMIC INSTABILITY
ATP-HYDROLYSIS
POLYMERIZATION DYNAMICS
ACTIN POLYMERIZATION
GROWING MICROTUBULES
GROWTH
BIOPOLYMERS
FILAMENTS
 
Description Collective dynamics and force generation by cytoskeletal filaments are crucial in many cellular processes. Investigating growth dynamics of a bundle of N independent cytoskeletal filaments pushing against a wall, we show that chemical switching (ATP/GTP hydrolysis) leads to a collective phenomenon that is currently unknown. Obtaining force-velocity relations for different models that capture chemical switching, we show, analytically and numerically, that the collective stall force of N filaments is greater than N times the stall force of a single filament. Employing an exactly solvable toy model, we analytically prove the above result for N = 2. We, further, numerically show the existence of this collective phenomenon, for N >= 2, in realistic models (with random and sequential hydrolysis) that simulate actin and microtubule bundle growth. We make quantitative predictions for the excess forces, and argue that this collective effect is related to the non-equilibrium nature of chemical switching.
 
Publisher IOP PUBLISHING LTD
 
Date 2014-12-29T06:17:05Z
2014-12-29T06:17:05Z
2014
 
Type Article
 
Identifier NEW JOURNAL OF PHYSICS, 16
1367-2630
http://dx.doi.org/10.1088/1367-2630/16/6/063032
http://dspace.library.iitb.ac.in/jspui/handle/100/17289
 
Language English