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Quantitative Proteomic Analysis of Meningiomas for the Identification of Surrogate Protein Markers

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Title Quantitative Proteomic Analysis of Meningiomas for the Identification of Surrogate Protein Markers
 
Creator SHARMA, S
RAY, S
MOIYADI, A
SRIDHAR, E
SRIVASTAVA, S
 
Subject CANCER PROTEOMICS
BRAIN-TUMORS
CLASSIFICATION
HETEROGENEITY
COAGULATION
POPULATION
BIOMARKERS
INTEGRINS
CELLS
 
Description Meningiomas are the most common non-glial tumors of the brain and spine. Pathophysiology and definite histological grading of meningiomas are frequently found to be deceptive due to their unusual morphological features and locations. Here for the first time we report a comprehensive serum proteomic analysis of different grades of meningiomas by using multiple quantitative proteomic and immunoassay-based approaches to obtain mechanistic insights about disease pathogenesis and identify grade specific protein signatures. In silico functional analysis revealed modulation of different vital physiological pathways including complement and coagulation cascades, metabolism of lipids and lipoproteins, immune signaling, cell growth and apoptosis and integrin signaling in meningiomas. ROC curve analysis demonstrated apolipoprotein E and A-I and hemopexin as efficient predictors for meningiomas. Identified proteins like vimentin, alpha-2-macroglobulin, apolipoprotein B and A-I and antithrombin-III, which exhibited a sequential increase in different malignancy grades of meningiomas, could serve as potential predictive markers.
 
Publisher NATURE PUBLISHING GROUP
 
Date 2015-01-15T10:32:06Z
2015-01-15T10:32:06Z
2014
 
Type Article
 
Identifier SCIENTIFIC REPORTS, 4
2045-2322
http://dx.doi.org/10.1038/srep07140
http://dspace.library.iitb.ac.in/jspui/handle/100/17347
 
Language en