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Formal Synthesis of the Human Rhinovirus 3C Protease Inhibitor (-)-Thysanone

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Title Formal Synthesis of the Human Rhinovirus 3C Protease Inhibitor (-)-Thysanone
 
Creator MULAY, SV
GHOLAP, SP
FERNANDES, RA
 
Subject 3C-PROTEASE INHIBITOR
ENANTIOSELECTIVE SYNTHESIS
STEREOSELECTIVE-SYNTHESIS
ANNULATION STRATEGY
(+)-NOCARDIONE B
NATURAL-PRODUCTS
DEOXY ANALOGS
IN-VITRO
THYSANONE
CLEAVAGE
Dotz benzannulation
human rhinovirus 3C protease
oxa-Pictet-Spengler reaction
pyranonaphthoquinones
(-)-thysanone
 
Description A strategy based on Dotz benzannulation and an oxa-Pictet-Spengler reaction toward the formal synthesis of a human rhinovirus (HRV) 3C protease inhibitor, the pyranonaphthoquinone (-)-thysanone, is presented.
 
Publisher WILEY-V C H VERLAG GMBH
 
Date 2016-01-14T10:21:21Z
2016-01-14T10:21:21Z
2015
 
Type Article
 
Identifier ASIAN JOURNAL OF ORGANIC CHEMISTRY, 4(6)560-566
2193-5807
2193-5815
http://dx.doi.org/10.1002/ajoc.201500070
http://dspace.library.iitb.ac.in/jspui/handle/100/17357
 
Language en