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A novel, compact and efficient microchannel arrangement with multiple hydrodynamic effects for blood plasma separation

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Title A novel, compact and efficient microchannel arrangement with multiple hydrodynamic effects for blood plasma separation
 
Creator PRABHAKAR, A
KUMAR, YVBV
TRIPATHI, S
AGRAWAL, A
 
Subject RED-CELL DISTRIBUTION
MICROFLUIDIC DEVICE
ASPECT-RATIO
WHOLE-BLOOD
FLOW
CHIP
SIZE
FRACTIONATION
PARTICLES
DEPLETION
Blood plasma separation
Elevated dimension micro-channel
Tau-shaped blood channel
Multiple-bend plasma channel
Multiple hydrodynamic effects
 
Description Separating plasma from blood using a microfluidic platform is favored and beneficial in point-of-care diagnostics. This paper presents a microdevice enabling blood plasma separation. In the present work, the microfluidic channel was innovatively designed in such a way that a combination of effects such as Fahraeus effect, bifurcation law, cell-free region, centrifugal action, and constriction-expansion is utilized together for skimming plasma from human blood. Microdevices were designed and fabricated using PDMS (poly-di-methyl siloxane), which is a bio-compatible material. The results obtained are extremely encouraging in terms of separation efficiency. Separation efficiency of almost 100 % has been achieved at moderate hematocrit contents of around 20 %. The separation efficiency for undiluted blood (hematocrit of 45 %) is around 80 %. This microdevice is free from clogging issues that are usually encountered in blood plasma separation devices.
 
Publisher SPRINGER HEIDELBERG
 
Date 2016-01-14T11:08:23Z
2016-01-14T11:08:23Z
2015
 
Type Article
 
Identifier MICROFLUIDICS AND NANOFLUIDICS, 18(42130)995-1006
1613-4982
1613-4990
http://dx.doi.org/10.1007/s10404-014-1488-6
http://dspace.library.iitb.ac.in/jspui/handle/100/17437
 
Language en