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Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin

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Title Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin
 
Creator TEWARI, D
AHMED, T
CHIRASANI, VR
SINGH, PK
MAJI, SK
SENAPATI, S
BERA, AK
 
Subject CYTOCHROME-C RELEASE
CELL-DEATH
PERMEABILITY TRANSITION
BCL-2 FAMILY
APOPTOSIS
MEMBRANE
PROTEINS
BAX
INVOLVEMENT
MECHANISMS
Ion channel
VDAC
Gating
Curcumin
Apoptosis
Mitochondria
 
Description Voltage dependent anion channel (VDAC) of mitochondria plays a crucial role in apoptosis. Human VDAC-1, reconstituted in planar lipid bilayer showed reduced conductance when treated with curcumin. Curcumin interacts with residues in the alpha helical N-terminus of VDAC and in the channel wall, as revealed by molecular docking, followed by mutational analysis. N-terminus mimicking peptide showed conformational changes in circular dichroism, upon curcumin treatment. We propose that the interaction of curcumin with amino acids in N-terminus and in channel wall fixes the alpha helix in closed conformation. This restricts its movement which is required for the opening of the channel. (C) 2014 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE BV
 
Date 2016-01-14T13:04:21Z
2016-01-14T13:04:21Z
2015
 
Type Article
 
Identifier BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1848(1A)151-158
0005-2736
0006-3002
http://dx.doi.org/10.1016/j.bbamem.2014.10.014
http://dspace.library.iitb.ac.in/jspui/handle/100/17568
 
Language en