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Constraints based analysis of extended cybernetic models

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Title Constraints based analysis of extended cybernetic models
 
Creator MANDLI, AR
VENKATESH, KV
MODAK, JM
 
Subject BACTERIAL-GROWTH
GENE-EXPRESSION
OPTIMAL STRATEGISTS
ADAPTIVE EVOLUTION
MICROBIAL-GROWTH
BEHAVIOR
METABOLISM
NETWORKS
KINETICS
MICROORGANISMS
Cybernetic model
Constraints based analysis
Linear growth
Optimal growth
 
Description The cybernetic modeling framework provides an interesting approach to model the regulatory phenomena occurring in microorganisms. In the present work, we adopt a constraints based approach to analyze the nonlinear behavior of the extended equations of the cybernetic model. We first show that the cybernetic model exhibits linear growth behavior under the constraint of no resource allocation for the induction of the key enzyme. We then quantify the maximum achievable specific growth rate of microorganisms on mixtures of substitutable substrates under various kinds of regulation and show its use in gaining an understanding of the regulatory strategies of microorganisms. Finally, we show that Saccharomyces cerevisiae exhibits suboptimal dynamic growth with a long diauxic lag phase when growing on a mixture of glucose and galactose and discuss on its potential to achieve optimal growth with a significantly reduced diauxic lag period. The analysis carried out in the present study illustrates the utility of adopting a constraints based approach to understand the dynamic growth strategies of microorganisms. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
 
Publisher ELSEVIER SCI LTD
 
Date 2016-01-14T13:08:22Z
2016-01-14T13:08:22Z
2015
 
Type Article
 
Identifier BIOSYSTEMS, 137,45-54
0303-2647
1872-8324
http://dx.doi.org/10.1016/j.biosystems.2015.09.001
http://dspace.library.iitb.ac.in/jspui/handle/100/17576
 
Language en