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Thermodynamic insights into drug-surfactant interactions: Study of the interactions of naporxen, diclofenac sodium, neomycin, and lincomycin with hexadecytrimethylammonium bromide by using isothermal titration calorimetry

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Title Thermodynamic insights into drug-surfactant interactions: Study of the interactions of naporxen, diclofenac sodium, neomycin, and lincomycin with hexadecytrimethylammonium bromide by using isothermal titration calorimetry
 
Creator CHOUDHARY, S
TALELE, P
KISHORE, N
 
Subject PHARMACOLOGICAL PROPERTIES
MICELLAR SOLUTIONS
NAPROXEN
INHIBITION
AGGREGATION
DEQUALINIUM
SCATTERING
DELIVERY
CHLORIDE
BINDING
Drug delivery
Micelles
Drug-partitioning
Isothermal titration calorimetry, Cationic surfactant
 
Description The success of drug delivery depends on the efficiency of the route of administration, which in turn relies on properties of the drug and its transport vehicle. A quantitative knowledge of association of drugs with transport vehicles is lacking when the latter are in the category of self assembled structures. The work reported in this manuscript addresses the mechanism of partitioning of naproxen, diclofenac sodium, neomycin and lincomycin in the micelles of hexadecytrimethylammonium bromide and that is quantitatively based on the measurement of thermodynamic parameters of interactions by using isothermal titration calorimetry. The addressed mechanism of partitioning is based on the identification of the type of interactions of these drugs with the surfactant micelles and monomers, along with the effect of the former on the micellization properties of the surfactant. The conclusions are based on the interpretation of the values of partitioning constant, standard molar enthalpy change, standard molar entropy change and the stoichiometry of the interaction. The results of this study have implications for deriving guidelines for the target oriented synthesis of new drugs that are to be used for effective delivery via micellar media. (c) 2015 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE BV
 
Date 2016-01-14T13:22:38Z
2016-01-14T13:22:38Z
2015
 
Type Article
 
Identifier COLLOIDS AND SURFACES B-BIOINTERFACES, 132,313-321
0927-7765
1873-4367
http://dx.doi.org/10.1016/j.colsurfb.2015.05.031
http://dspace.library.iitb.ac.in/jspui/handle/100/17604
 
Language en